Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity

Chem Commun (Camb). 2011 Jun 21;47(23):6575-7. doi: 10.1039/c1cc11356a. Epub 2011 May 9.

Abstract

The conjugation of arginine residues at the ends of a metallo-supramolecular triple-helical cylinder enables absolute control over the helicity of the cylinder core, and boosts the DNA junction recognition by the complexes and their activity against a cancer cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arginine / chemistry*
  • Cell Line, Tumor
  • Coordination Complexes / chemistry*
  • Coordination Complexes / toxicity
  • DNA / chemistry*
  • Ferrous Compounds / chemistry
  • Humans
  • Metals / chemistry*
  • Nucleic Acid Conformation

Substances

  • Coordination Complexes
  • Ferrous Compounds
  • Metals
  • DNA
  • Arginine