A catheter (5Fr) was inserted and placed via the left radial artery in the common or proper hepatic artery for intra-hepato-arterial infusion chemotherapy in 26 cases of liver malignancy. The patients for the chemotherapy included 15 cases of primary hepatocellular carcinoma, five cases of metastatic gastric carcinoma, 3 cases of metastatic colorectal carcinoma, one case of metastatic leiomyosarcoma, one case of metastatic bile duct carcinoma and one case of metastatic melanoma. A large-bore catheter was successfully inserted via the left radial artery, and transcatheter arterial embolization therapy (TAE) was performed on 8 cases during the infusion chemotherapy using the same catheter. One case developed cerebellar infarction after the insertion of the catheter, but no other serious complication developed during the therapy using this technique. It is easy to insert or remove the catheter via the left radial artery. This technique is useful in intra-hepato-arterial infusion chemotherapy on liver malignancy.