Abstract
Binary combinations of cisplatin and the 5-HT3 antagonist, BRL 43694, have been used to treat both conventional mice bearing either L1210 leukaemia or ADJ/PC6 plasmacytoma and nude mice xenografted with a human ovarian carcinoma (HX/110). In no case was there evidence for antagonism by the antiemetic of the antitumour properties of cisplatin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cisplatin / administration & dosage
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Cisplatin / therapeutic use*
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Drug Interactions
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Drug Therapy, Combination
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Granisetron
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Indazoles / administration & dosage
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Indazoles / therapeutic use*
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Leukemia L1210 / drug therapy
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Neoplasm Transplantation
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Neoplasms, Experimental / drug therapy*
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Plasmacytoma / drug therapy
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Pyrazoles / therapeutic use*
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Serotonin Antagonists / administration & dosage
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Serotonin Antagonists / therapeutic use*
Substances
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Indazoles
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Pyrazoles
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Serotonin Antagonists
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Cisplatin
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Granisetron