The tale of TL1A in inflammation

H Hsu; J L Viney

doi:10.1038/mi.2011.20

The tale of TL1A in inflammation

Mucosal Immunol. 2011 Jul;4(4):368-70. doi: 10.1038/mi.2011.20. Epub 2011 May 4.

Authors

H Hsu¹, J L Viney

Affiliation

¹ Department of Inflammation, Amgen Inc., Thousand Oaks, California, USA. hhsu@amgen.com

PMID: 21544073
DOI: 10.1038/mi.2011.20

Abstract

TL1A (also known as TNFSF15) is a tumor necrosis factor (TNF) family member expressed by monocytes, macrophages, dendritic cells (DCs), synovial fibroblasts, and endothelial cells in response to stimulation by cytokines, immune complexes, and microorganisms. Its cell surface receptor, DR3 (also known as TNFSF25, WSL-1, TRAMP, and LARD), is mainly expressed by T cells.

Publication types

Review
Comment

MeSH terms

Animals
Enteritis / immunology*
Gene Expression Regulation*
Goblet Cells / immunology*
Humans
Hyperplasia / immunology*
Interleukin-13 / immunology*
Intestinal Mucosa / immunology*
Intestinal Mucosa / pathology*
T-Lymphocytes, Regulatory / immunology*
Tumor Necrosis Factor Ligand Superfamily Member 15 / immunology*

Substances

Interleukin-13
Tumor Necrosis Factor Ligand Superfamily Member 15