Presence of HPV DNA in placenta and cervix of pregnant Mexican women

Arch Gynecol Obstet. 2012 Jan;285(1):55-60. doi: 10.1007/s00404-011-1911-0. Epub 2011 May 3.

Abstract

Purpose: To identify the presence of HPV DNA in cervical as well as in placental tissue of pregnant Mexican women and to determine which type is more frequent.

Methods: In a cross-sectional study, 56 placental samples were obtained from 72 pregnant women. HPV DNA was extracted and amplified with polymerase chain reaction using a consensus primer and then identified by type using RsaI endonuclease. The main outcome measures were placenta with/without HPV relation and HPV types in placenta.

Results: HPV DNA was identified in 75% of cervical tissue samples and 47.2% of placental tissue samples. Type 18 was the most frequently identified HPV type.

Conclusions: There was a higher frequency of HPV DNA found in the cervix of Mexican women during pregnancy than reported in the previous studies. Its identification in full-term placental tissue has no relation to the type of delivery in childbirth.

MeSH terms

  • Adolescent
  • Adult
  • Cervix Uteri / chemistry
  • Cervix Uteri / virology*
  • Cross-Sectional Studies
  • DNA, Viral / analysis
  • DNA, Viral / metabolism*
  • Female
  • Humans
  • Mexico / epidemiology
  • Papillomavirus Infections / diagnosis*
  • Papillomavirus Infections / epidemiology
  • Papillomavirus Infections / virology
  • Placenta / chemistry
  • Placenta / virology*
  • Pregnancy
  • Pregnancy Outcome
  • Young Adult

Substances

  • DNA, Viral