Syntheses of α-pyrones using gold-catalyzed coupling reactions

Org Lett. 2011 Jun 3;13(11):2834-6. doi: 10.1021/ol200794w. Epub 2011 May 2.

Abstract

Sequential alkyne activation of terminal alkynes and propiolic acids by gold(I) catalysts yields compounds having α-pyrone skeletons. Novel cascade reactions involving propiolic acids are reported that give rise to α-pyrones with different substitution patterns.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Catalysis
  • Cyclization
  • Gold / chemistry*
  • Molecular Structure
  • Propionates / chemistry*
  • Pyrones / chemical synthesis*
  • Pyrones / chemistry*
  • Stereoisomerism

Substances

  • Alkynes
  • Propionates
  • Pyrones
  • Gold
  • propiolic acid