Translational control by the eukaryotic ribosome

Ivan Topisirovic; Nahum Sonenberg

doi:10.1016/j.cell.2011.04.006

Translational control by the eukaryotic ribosome

Cell. 2011 Apr 29;145(3):333-4. doi: 10.1016/j.cell.2011.04.006.

Authors

Ivan Topisirovic¹, Nahum Sonenberg

Affiliation

¹ Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada. ivan.topisirovic@mcgill.ca

PMID: 21529706
DOI: 10.1016/j.cell.2011.04.006

Abstract

The ribosome plays a universally conserved role in catalyzing protein synthesis. Kondrashov et al. (2011) now provide evidence that the loss of function of ribosomal protein L38 in mice leads to a selective reduction in the translation of Hox mRNAs, thus suggesting that ribosomal proteins play a critical role during embryonic development.

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