Abstract
A Pseudomonas aeruginosa highly resistant to carbapenems was isolated in a neonatal intensive care unit in Palermo, Italy. The strain was found to carry a novel VIM-type enzyme, classified as VIM-14. The novel enzyme differs from VIM-4 in a G31S mutation. VIM-14 was harboured in a class 1 integron with a new organization. The integron carried the genes aac7, blaVIM-14, blaOXA-20 and aac4 in that order.
© 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.
MeSH terms
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Base Sequence
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Carbapenems / pharmacology
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DNA, Bacterial / genetics
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Drug Resistance, Multiple, Bacterial / genetics
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Humans
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Infant, Newborn
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Integrons* / drug effects
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Intensive Care Units, Neonatal*
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / enzymology*
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Pseudomonas aeruginosa / genetics
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Pseudomonas aeruginosa / isolation & purification*
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Sequence Analysis, DNA
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Carbapenems
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DNA, Bacterial
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beta-Lactamases