Steroids and extracellular signal-regulated kinase 1/2 activity suppress activating transcription factor 3 expression in patients with severe asthma

J Allergy Clin Immunol. 2011 Jun;127(6):1632-4. doi: 10.1016/j.jaci.2011.03.034. Epub 2011 Apr 22.

Authors

Lucie Roussel, Stephanie Robins, Amanda Schachter, Julie Bérubé, Qutayba Hamid, Simon Rousseau

PMID: 21514952
DOI: 10.1016/j.jaci.2011.03.034

No abstract available

Publication types

Letter

MeSH terms

Activating Transcription Factor 3 / genetics*
Activating Transcription Factor 3 / metabolism*
Adult
Asthma / drug therapy*
Asthma / genetics
Asthma / metabolism*
Base Sequence
Case-Control Studies
Cell Line
DNA Primers / genetics
Extracellular Signal-Regulated MAP Kinases / metabolism*
Gene Expression / drug effects
Glucocorticoids / pharmacology*
Humans
RNA, Messenger / genetics
RNA, Messenger / metabolism
Toll-Like Receptor 3 / agonists
Toll-Like Receptor 9 / agonists
Tumor Necrosis Factor-alpha / pharmacology

Substances

ATF3 protein, human
Activating Transcription Factor 3
DNA Primers
Glucocorticoids
RNA, Messenger
TLR3 protein, human
TLR9 protein, human
Toll-Like Receptor 3
Toll-Like Receptor 9
Tumor Necrosis Factor-alpha
Extracellular Signal-Regulated MAP Kinases