Synthesis and antibacterial activity of alaremycin derivatives for the porphobilinogen synthase

Bioorg Med Chem Lett. 2011 May 15;21(10):2812-5. doi: 10.1016/j.bmcl.2011.03.106. Epub 2011 Apr 7.

Abstract

The preparation and the antibacterial activity of alaremycin derivatives such as their CF(3)-derivatives and (R)- and (S)-4-oxo-5-acetylaminohexanoic acid for the porphobilinogen synthase (PBGS), were described. The IC(50) values of the antibacterial activity of the prepared materials for the inhibitor of PBGS, were determined using PBGS assay.

MeSH terms

  • Aminocaproates / chemical synthesis*
  • Aminocaproates / chemistry
  • Aminocaproates / pharmacology*
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Biological Assay
  • Chlorofluorocarbons, Methane / chemistry
  • Inhibitory Concentration 50
  • Molecular Structure
  • Porphobilinogen Synthase / antagonists & inhibitors*
  • Porphobilinogen Synthase / chemistry
  • Pseudomonas / drug effects*

Substances

  • Aminocaproates
  • Anti-Bacterial Agents
  • Chlorofluorocarbons, Methane
  • alaremycin
  • Porphobilinogen Synthase
  • fluoroform