Safe and successful treatment with erlotinib after gefitinib-induced hepatotoxicity: difference in metabolism as a possible mechanism

MeSH terms

• Aged
• Aged, 80 and over
• Carcinoma, Non-Small-Cell Lung / drug therapy*
• Carcinoma, Non-Small-Cell Lung / genetics
• Chemical and Drug Induced Liver Injury / etiology*
• ErbB Receptors / genetics
• Erlotinib Hydrochloride
• Female
• Gefitinib
• Humans
• Japan
• Liver / drug effects*
• Lung Neoplasms / drug therapy*
• Lung Neoplasms / genetics
• Mutation
• Quinazolines / adverse effects*
• Quinazolines / pharmacology*
• Transaminases / biosynthesis
• Treatment Outcome