Evaluating the clonal hierarchy in light-chain multiple myeloma: implications against the myeloma stem cell hypothesis

Leukemia. 2011 Jul;25(7):1213-6. doi: 10.1038/leu.2011.70. Epub 2011 Apr 15.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Lineage
  • Cell Separation
  • Cell Transformation, Neoplastic*
  • Chromosomes, Human, Pair 14 / genetics
  • Chromosomes, Human, Pair 14 / ultrastructure
  • Clone Cells / pathology*
  • Flow Cytometry
  • Gene Rearrangement, B-Lymphocyte, Light Chain*
  • Humans
  • Immunoglobulin Class Switching
  • Immunoglobulin Light Chains / genetics*
  • Immunoglobulin Variable Region / genetics*
  • Models, Biological*
  • Multiple Myeloma / genetics
  • Multiple Myeloma / pathology*
  • Myeloma Proteins / genetics*
  • Neoplastic Stem Cells / pathology*
  • Phenotype
  • Somatic Hypermutation, Immunoglobulin
  • Translocation, Genetic

Substances

  • Immunoglobulin Light Chains
  • Immunoglobulin Variable Region
  • Myeloma Proteins