In this work, we measured the changes of atrial natriuretic polypeptide, (ANP) and angiotensin (AII) in plasma of normal and hemorrhagic shock rabbits by the radioimmunoassay (PIA). Meanwhile, we observed the effect of acupuncture on the changes of ANP and AII in plasma of hemorrhagic shock rabbits. The results showed that the contents of ANP and AII in plasma increased when the hemorrhagic shock extended. Acupunctured at "Neiguan" can anti-shock by increasing blood pressure and can decrease the ANP and AII in plasma. Shock may promote the secretion and reduce the disintegration of ANP. Acupuncture can anti-shock by increasing blood pressure and correcting the disturbance of secretion and metabolism of ANP and AII during shock.