Abstract
This pilot study describes a relationship between insulin resistance and μ-opioid neurotransmission in limbic appetite and mood-regulating regions in women with polycystic ovary syndrome (PCOS), suggesting that insulin-opioid interactions may contribute to behavioral and reproductive pathologies of PCOS. We found that [1] patients with PCOS who are insulin-resistant (n = 7) had greater limbic μ-opioid receptor availability (nondisplaceable binding potential) than controls (n = 5); [2] receptor availability was correlated with severity of insulin resistance; and [3] receptor availability normalized after insulin-regulating treatment.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Binding Sites
-
Brain / drug effects
-
Brain / metabolism*
-
Carbon Radioisotopes
-
Case-Control Studies
-
Female
-
Fentanyl / analogs & derivatives
-
Fentanyl / metabolism
-
Glucose Tolerance Test
-
Humans
-
Hypoglycemic Agents / therapeutic use
-
Insulin Resistance*
-
Magnetic Resonance Imaging
-
Metformin / therapeutic use
-
Michigan
-
Pilot Projects
-
Polycystic Ovary Syndrome / drug therapy
-
Polycystic Ovary Syndrome / metabolism*
-
Polycystic Ovary Syndrome / physiopathology
-
Positron-Emission Tomography
-
Receptors, Opioid, mu / drug effects
-
Receptors, Opioid, mu / metabolism*
-
Time Factors
-
Treatment Outcome
-
Young Adult
-
beta-Endorphin / metabolism*
Substances
-
Carbon Radioisotopes
-
Hypoglycemic Agents
-
Receptors, Opioid, mu
-
beta-Endorphin
-
Metformin
-
carfentanil
-
Fentanyl