Calcific tendinopathy of the rotator cuff is a chronic disease that mostly in the acute phase compromises the articular function. The aim of this study is to estimate the effectiveness of the ultrasonic-guided percutaneous treatment (UGPT) in association with the rehabilitative treatment. We evaluated 106 patients with calcific tendinopathy, treated by UGPT. They underwent clinical evaluation by a physiatrist at T0 (the same day of UGPT), and were reassessed at follow-up 1 month (T1) after treatment. The assessment at T0 and T1 was done by the Constant-Murley scale. Analyzing the results, we found that at T0, the average Constant score was 43.5 out of 100; at T1 it was 83.2 out of 100. The improvement was statistically significant (P < 0.0005). We found that UGPT and rehabilitation associated with the multidisciplinary management of the patient (orthopedic surgeon-radiologist-physiatrist) was able to prevent adhesive bursitis, and to achieve clinical cure in most of the treated cases.