Activation of D1 dopamine receptors stimulates the release of GABA in the basal ganglia of the rat

Neurosci Lett. 1990 Aug 14;116(1-2):136-40. doi: 10.1016/0304-3940(90)90399-t.

Abstract

Here we have explored whether dopamine is able to modulate the release of gamma-aminobutyric acid (GABA) from striatal terminals to substantia nigra pars reticulata, entopeduncular nucleus, globus pallidus and caudate-putamen. The type of dopamine receptors involved was assessed by the blocking effect of either SCH 23390 (D1 antagonist) or (-)-sulpiride (D2 antagonist) of the dopamine effect. Dopamine stimulated (EC50 3.2 microM) the depolarization-induced release of [3H]GABA from slices isolated from all of the above mentioned nuclei. SCH 23390 dose-dependently blocked the dopamine stimulation, but (-)-sulpiride did not show any blocking effect. The results suggest that dopamine via D1 receptors modulates the release of GABA from striatal GABAergic terminals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Basal Ganglia / drug effects
  • Basal Ganglia / physiology*
  • Benzazepines / pharmacology
  • Caudate Nucleus / drug effects
  • Caudate Nucleus / physiology
  • Corpus Striatum / drug effects
  • Corpus Striatum / physiology
  • Dopamine / pharmacology*
  • Globus Pallidus / drug effects
  • Globus Pallidus / physiology
  • Hydroxydopamines
  • In Vitro Techniques
  • Male
  • Oxidopamine
  • Putamen / drug effects
  • Putamen / physiology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / physiology*
  • Receptors, Dopamine D1
  • Substantia Nigra / drug effects
  • Substantia Nigra / physiology*
  • Sulpiride / pharmacology
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Benzazepines
  • Hydroxydopamines
  • Receptors, Dopamine
  • Receptors, Dopamine D1
  • gamma-Aminobutyric Acid
  • Sulpiride
  • Oxidopamine
  • Dopamine