Solid-phase synthesis of H-Phe-Tyr-(pATAT)-NH2: a nucleopeptide fragment from the nucleoprotein of bacteriophage phi X174

C M Dreef-Tromp; E M van Dam; H van den Elst; G A van der Marel; J H van Boom

doi:10.1093/nar/18.22.6491

Solid-phase synthesis of H-Phe-Tyr-(pATAT)-NH2: a nucleopeptide fragment from the nucleoprotein of bacteriophage phi X174

Nucleic Acids Res. 1990 Nov 25;18(22):6491-5. doi: 10.1093/nar/18.22.6491.

Authors

C M Dreef-Tromp¹, E M van Dam, H van den Elst, G A van der Marel, J H van Boom

Affiliation

¹ Gorlaeus Laboratories, Leiden, The Netherlands.

Abstract

The preparation of the nucleopeptide H-Phe-Tyr-(pATAT)-NH2 could be realized via a solid phase phosphitetriester approach and by using the protected protecting group 2-(tert-butyldiphenylsilyoxymethyl)-benzoyl for the masking of the N6-amino function of deoxyadenosine. The latter protecting group can be removed under mild conditions with fluoride ion.

MeSH terms

Bacteriophage phi X 174* / analysis
Chromatography
Nucleoproteins / chemical synthesis*
Oligopeptides / chemical synthesis*

Substances

Nucleoproteins
Oligopeptides