Comparison between surgical outcomes of colorectal cancer in younger and elderly patients

World J Gastroenterol. 2011 Mar 28;17(12):1642-8. doi: 10.3748/wjg.v17.i12.1642.

Abstract

Aim: To compare the outcome of surgical treatment of colorectal adenocarcinoma in elderly and younger patients.

Methods: The outcomes of 122 patients with colorectal adenocarcinoma who underwent surgical treatment between January 2004 and June 2009 were analyzed. The clinicopathological and blood biochemistry data of the younger group (< 75 years) and the elderly group (≥ 75 years) were compared.

Results: There were no significant differences between the two groups in operation time, intraoperative blood loss, hospital stay, time to resumption of oral intake, or morbidity. The elderly group had a significantly higher rate of hypertension and cardiovascular disease. The perioperative serum total protein and albumin levels were significantly lower in the elderly than in the younger group. The serum carcinoembryonic antigen level was lower in the elderly than in the younger group, and there was a significant decreasing trend after the operation in the elderly group.

Conclusion: The short-term outcomes of surgical treatment in elderly patients with colorectal adenocarcinoma were acceptable. Surgical treatment in elderly patients was considered a selectively effective approach.

Keywords: C-reactive protein; Carcinoembryonic antigen; Colorectal tumor; Elderly patient; Morbidity.

Publication types

  • Comparative Study

MeSH terms

  • Adenocarcinoma / blood
  • Adenocarcinoma / pathology
  • Adenocarcinoma / surgery*
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Blood Loss, Surgical
  • Carcinoembryonic Antigen / blood
  • Colectomy* / adverse effects
  • Colorectal Neoplasms / blood
  • Colorectal Neoplasms / pathology
  • Colorectal Neoplasms / surgery*
  • Eating
  • Female
  • Humans
  • Japan
  • Length of Stay
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Nutritional Status
  • Patient Selection
  • Recovery of Function
  • Risk Assessment
  • Risk Factors
  • Serum Albumin / metabolism
  • Time Factors
  • Treatment Outcome

Substances

  • Carcinoembryonic Antigen
  • Serum Albumin