A palladium-catalyzed three-component cross-coupling of conjugated dienes or terminal alkenes with vinyl triflates and boronic acids

J Am Chem Soc. 2011 Apr 20;133(15):5784-7. doi: 10.1021/ja201358b. Epub 2011 Mar 30.

Abstract

A three-component coupling of vinyl triflates and boronic acids to alkenes catalyzed by palladium is reported. Using 1,3-dienes, selective 1,2-alkene difunction-alization is observed, whereas the use of terminal alkenes results in 1,1-alkene difunctionalization. The reaction outcome is attributed to the formation of stabilized, cationic Pd-π-allyl intermediates to regulate β-hydride elimination.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alkenes / chemistry*
  • Boronic Acids / chemistry*
  • Catalysis
  • Mesylates / chemistry*
  • Palladium / chemistry
  • Vinyl Compounds / chemistry*

Substances

  • Alkenes
  • Boronic Acids
  • Mesylates
  • Vinyl Compounds
  • vinyl triflate
  • Palladium