Abstract
Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.
Publication types
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Historical Article
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Bicuculline / pharmacology
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Biophysics
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Convulsants / pharmacology
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Deep Brain Stimulation / history
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Deep Brain Stimulation / methods*
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Disease Models, Animal
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GABA-A Receptor Agonists / therapeutic use
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History, 20th Century
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Humans
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Macaca
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Male
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Muscimol / therapeutic use
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Parkinson Disease / etiology
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Parkinson Disease / therapy
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Pedunculopontine Tegmental Nucleus / physiology*
Substances
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Convulsants
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GABA-A Receptor Agonists
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Muscimol
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Bicuculline