[Specific enzymatic amplification of a DNA region closely associated with Huntington chorea]

G Novelli; P Mandich; A Ruzzo; F Mannello; F Ajmar; B Dallapiccola

[Specific enzymatic amplification of a DNA region closely associated with Huntington chorea]

Boll Soc Ital Biol Sper. 1990 May;66(5):419-25.

[Article in Italian]

Authors

G Novelli¹, P Mandich, A Ruzzo, F Mannello, F Ajmar, B Dallapiccola

Affiliation

¹ Cattedra di Genetica, Università di Urbino.

PMID: 2144430

Abstract

Enzymatic DNA amplification has become a new important tool in the analysis of human genome. We report the use of this new technique for the detection of a polymorphic DNA sequence adjacent to the Huntington's disease locus for presymptomatic and prenatal testing of the disease.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Family Health
Humans
Huntington Disease / genetics*
Polymerase Chain Reaction