Regiocontrolled rearrangement of isobenzofurans

Ben A Egan; Michael Paradowski; Lynne H Thomas; Rodolfo Marquez

doi:10.1021/ol200498k

Regiocontrolled rearrangement of isobenzofurans

Org Lett. 2011 Apr 15;13(8):2086-9. doi: 10.1021/ol200498k. Epub 2011 Mar 23.

Authors

Ben A Egan¹, Michael Paradowski, Lynne H Thomas, Rodolfo Marquez

Affiliation

¹ WestCHEM, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ, United Kingdom.

PMID: 21428447
DOI: 10.1021/ol200498k

Abstract

The regioselective alkylation and oxidative rearrangement of isobenzofurans has been achieved to generate substituted 4,8-dihydroxyisochromanones in good yields and with complete regiocontrol.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkylation
Benzofurans / chemistry*
Models, Molecular
Molecular Structure
Oxidation-Reduction
Stereoisomerism

Substances

Benzofurans