Moving closer to a prognostic DNA methylation signature in colon cancer

Clin Cancer Res. 2011 Mar 15;17(6):1215-7. doi: 10.1158/1078-0432.CCR-10-3446.

Abstract

Although large panels of genes undergoing aberrant CpG island methylation in colorectal cancer have been identified, reliable predictors for clinical management in this tumor type remain elusive. A new DNA methylation signature affecting the extracellular matrix (ECM) pathway has been identified with potential prognostic value in colon cancer.

Publication types

  • Comment

MeSH terms

  • Cohort Studies
  • Colonic Neoplasms / diagnosis*
  • Colonic Neoplasms / genetics*
  • CpG Islands
  • DNA Methylation*
  • Extracellular Matrix / metabolism
  • Gene Expression Profiling
  • Humans
  • Medical Oncology / methods
  • Prognosis
  • Recurrence