Two new compounds from an endophytic fungus Aspergillus sp. HS-05

J Asian Nat Prod Res. 2011 Mar;13(3):225-9. doi: 10.1080/10286020.2010.550885.

Abstract

Two new compounds, N-[4'-hydroxy-(E)-cinnamoyl]-l-tyrosine methyl ester (1) and methyl 4-methoxy-3-(3'-hydroxy-2'-methyl)propionyloxy-benzoate (2), were isolated from EtOAc extract of the fermentation broth of the endophytic fungus Aspergillus sp. HS-05. Their structures were elucidated by NMR, IR, UV, MS, and CD methods. Compounds 1 and 2 showed no anticancer activities against HL-60 cell lines (both of IC(50)>100 μM) in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Aspergillus / chemistry*
  • Benzoates / chemistry
  • Benzoates / isolation & purification*
  • Benzoates / pharmacology
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • HL-60 Cells
  • Humans
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Leaves / chemistry
  • Tyrosine / analogs & derivatives*
  • Tyrosine / chemistry
  • Tyrosine / isolation & purification
  • Tyrosine / pharmacology

Substances

  • Antineoplastic Agents
  • Benzoates
  • Drugs, Chinese Herbal
  • N-(4'-hydroxy-(E)-cinnamoyl)-L-tyrosine methyl ester
  • methyl 4-methoxy-3-(3'-hydroxy-2'-methyl)propionyloxybenzoate
  • tyrosine methyl ester
  • Tyrosine