Abiotrophia defectiva infection of a total hip arthroplasty diagnosed by 16S rRNA gene sequencing

Diagn Microbiol Infect Dis. 2011 May;70(1):142-4. doi: 10.1016/j.diagmicrobio.2010.11.016. Epub 2011 Mar 9.

Abstract

We describe a case of a total hip arthroplasty infection caused by Abiotrophia defectiva, identified by 16S rRNA gene sequencing. Removal of the prosthesis followed by antibiotic treatment resulted in a good clinical outcome. 16S rRNA gene sequencing can be a useful tool in diagnosing infection with this fastidious microorganism that can easily be misidentified using phenotypic identification methods.

Publication types

  • Case Reports

MeSH terms

  • Abiotrophia / genetics
  • Abiotrophia / isolation & purification*
  • Aged
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacology
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • DNA, Ribosomal / chemistry
  • DNA, Ribosomal / genetics
  • Female
  • Gram-Positive Bacterial Infections / diagnosis*
  • Gram-Positive Bacterial Infections / drug therapy
  • Gram-Positive Bacterial Infections / microbiology
  • Gram-Positive Bacterial Infections / surgery
  • Hip Joint / diagnostic imaging
  • Hip Joint / surgery
  • Hip Prosthesis / adverse effects
  • Humans
  • Microbial Sensitivity Tests
  • Microscopy
  • Prosthesis-Related Infections / diagnosis*
  • Prosthesis-Related Infections / drug therapy
  • Prosthesis-Related Infections / microbiology
  • Prosthesis-Related Infections / surgery
  • RNA, Ribosomal, 16S / genetics
  • Radiography
  • Sequence Analysis, DNA

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • DNA, Ribosomal
  • RNA, Ribosomal, 16S