Abstract
We expanded second-line tuberculosis (TB) drug susceptibility testing for extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa. Of 19 patients with extensively drug-resistant TB identified during February 2008-April 2009, 13 (68%) had isolates resistant to all 8 drugs tested. This resistance leaves no effective treatment with available drugs in South Africa.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antitubercular Agents / pharmacology*
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Antitubercular Agents / therapeutic use
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Drug Resistance, Multiple, Bacterial* / drug effects
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Extensively Drug-Resistant Tuberculosis / drug therapy
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Extensively Drug-Resistant Tuberculosis / epidemiology*
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Extensively Drug-Resistant Tuberculosis / microbiology
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Female
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Humans
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / isolation & purification
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South Africa / epidemiology
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Tuberculosis, Multidrug-Resistant / drug therapy
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Tuberculosis, Multidrug-Resistant / epidemiology
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Tuberculosis, Multidrug-Resistant / microbiology
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Young Adult