Effect of bevacizumab on postoperative adhesion formation in a rat uterine horn adhesion model and the correlation with vascular endothelial growth factor and Ki-67 immunopositivity

Fertil Steril. 2011 Jun 30;95(8):2638-41. doi: 10.1016/j.fertnstert.2011.02.005. Epub 2011 Mar 9.

Abstract

We investigated whether adhesion formation is prevented by the inhibition of angiogenesis in a rat uterine horn adhesion model. A single-dose of bevacizumab was effective in preventing postoperative intraperitoneal adhesion formation among 30 Wistar albino rats that underwent serosal injury by use of a standard technique after laparotomy with intraperitoneal bevacizumab.

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage
  • Angiogenesis Inhibitors / pharmacology*
  • Animals
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal / pharmacology*
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab
  • Female
  • Gynecologic Surgical Procedures / adverse effects*
  • Immunohistochemistry*
  • Injections, Intraperitoneal
  • Ki-67 Antigen / metabolism*
  • Rats
  • Rats, Wistar
  • Tissue Adhesions
  • Uterine Diseases / etiology
  • Uterine Diseases / metabolism
  • Uterine Diseases / pathology
  • Uterine Diseases / prevention & control*
  • Uterus / blood supply
  • Uterus / metabolism
  • Uterus / pathology
  • Uterus / surgery*
  • Vascular Endothelial Growth Factor A / metabolism*

Substances

  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Ki-67 Antigen
  • Vascular Endothelial Growth Factor A
  • vascular endothelial growth factor A, rat
  • Bevacizumab