Abstract
The National Cancer Institute of Canada Clinical Trials Group conducted a phase II trial of trimetrexate given in a daily x 5 intravenous bolus schedule every 3 weeks in patients with measurable recurrent anaplastic glioma and limited prior treatment. There were no responses in 14 evaluable patients. We conclude that trimetrexate, given as described, is not an active agent in this disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / therapeutic use*
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Canada
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Drug Evaluation
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Female
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Glioma / drug therapy*
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Humans
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Injections, Intravenous
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Male
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Middle Aged
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Quinazolines / administration & dosage
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Quinazolines / therapeutic use*
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Trimetrexate
Substances
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Antineoplastic Agents
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Quinazolines
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Trimetrexate