Hepatocyte plasma membrane ECTO-ATPase (pp120/HA4) is a substrate for tyrosine kinase activity of the insulin receptor

Biochem Biophys Res Commun. 1990 Jan 30;166(2):562-6. doi: 10.1016/0006-291x(90)90845-e.

Abstract

pp120/HA4, a membrane protein found in hepatocyte plasma membranes and a substrate for the insulin receptor tyrosine kinase, was purified to homogeneity, subjected to partial proteolysis, and peptides were sequenced by Edman degradation. Six amino acid sequences were obtained, and they matched the deduced amino acid sequences of six regions of a hepatocyte membrane protein called ecto-ATPase.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blotting, Western
  • Calcium-Transporting ATPases / metabolism*
  • Liver / enzymology*
  • Membrane Glycoproteins / metabolism*
  • Molecular Sequence Data
  • Molecular Weight
  • Peptide Mapping
  • Phosphorylation
  • Rats
  • Receptor, Insulin / metabolism*

Substances

  • Membrane Glycoproteins
  • Receptor, Insulin
  • Calcium-Transporting ATPases