The effect of polymeric additives on the solubilisation of a poorly-soluble drug in micellar solutions of Pluronic F127

Int J Pharm. 2011 May 16;409(1-2):206-8. doi: 10.1016/j.ijpharm.2011.02.025. Epub 2011 Feb 25.

Abstract

The solubilisation of griseofulvin in 1wt% aqueous micellar solutions of Pluronic F127 at 37°C has been modified by adding polyethylene glycol PEG 35000 or poly(vinylpyrrolidone) PVP K30. The solubilisation capacity expressed in terms of unit weight of F127 is increased by the addition of 0.5wt% PEG 35000 to a value approaching double that of a 2.5wt% solution of F127 alone, but there is no advantage in adding 0.5wt% PVP K30.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Excipients / chemistry
  • Griseofulvin / administration & dosage
  • Griseofulvin / chemistry*
  • Micelles
  • Pharmaceutical Solutions
  • Poloxamer / chemistry*
  • Polyethylene Glycols / chemistry*
  • Polymers / chemistry
  • Povidone / chemistry*
  • Solubility

Substances

  • Excipients
  • Micelles
  • Pharmaceutical Solutions
  • Polymers
  • Poloxamer
  • Griseofulvin
  • Polyethylene Glycols
  • Povidone