More than 22,000 people attended the 2010 European Respiratory Society conference. Numerous scientific sessions discussed TB themes (e.g., European and global epidemiology, management of drug-resistant TB, TB in vulnerable populations, and bacteriological and immunological diagnosis). In particular, several authors emphasized the increasing trend of TB in Europe, highlighting the need for public health programs focused on vulnerable populations: frequently, these populations are infected with drug-resistant strains and their clinical and treatment outcomes could be poor, with the consequence of increasing the risk of ongoing mycobacterial transmission. Other interesting reports were focused on IFN-γ release assays, which show a good diagnostic performance in different clinical conditions, even though their role needs to be clarified in well-designed analytic studies.