Levantilides A and B, 20-membered macrolides from a Micromonospora strain isolated from the Mediterranean deep sea sediment

Mar Drugs. 2011 Jan 14;9(1):98-108. doi: 10.3390/md9010098.

Abstract

Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6 ‰. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines.

Keywords: Micromonospora; deep sea; macrolide; marine; natural product.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification*
  • Anti-Infective Agents / metabolism
  • Anti-Infective Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology
  • Aquatic Organisms
  • Bacteria / drug effects
  • Drug Screening Assays, Antitumor
  • Environment
  • Fungi / drug effects
  • Geologic Sediments / microbiology*
  • Humans
  • Macrolides / chemistry
  • Macrolides / isolation & purification*
  • Macrolides / metabolism
  • Macrolides / pharmacology
  • Mediterranean Sea
  • Microbial Sensitivity Tests
  • Micromonospora / chemistry*
  • Micromonospora / isolation & purification
  • Phylogeny

Substances

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Macrolides