Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance

Leukemia. 2011 May;25(5):877-9. doi: 10.1038/leu.2011.10. Epub 2011 Feb 22.
No abstract available

Publication types

  • Letter

MeSH terms

  • Biomarkers, Tumor / genetics*
  • Biomarkers, Tumor / metabolism
  • DNA-Binding Proteins / genetics*
  • Dioxygenases
  • Enhancer of Zeste Homolog 2 Protein
  • Gene Expression Profiling*
  • Humans
  • Leukemia, Myelomonocytic, Chronic / genetics*
  • Mutation / genetics*
  • Oligonucleotide Array Sequence Analysis
  • Polycomb Repressive Complex 2
  • Prognosis
  • Proto-Oncogene Proteins / genetics*
  • Survival Rate
  • Transcription Factors / genetics*

Substances

  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Transcription Factors
  • Dioxygenases
  • TET2 protein, human
  • EZH2 protein, human
  • Enhancer of Zeste Homolog 2 Protein
  • Polycomb Repressive Complex 2