Abstract
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Biological Transport / physiology
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Blood-Brain Barrier / drug effects
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Blood-Brain Barrier / metabolism*
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Brain / drug effects
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Brain / metabolism
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Cerebrovascular Circulation / drug effects
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Cerebrovascular Circulation / physiology
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Humans
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Nervous System Diseases / drug therapy
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Nervous System Diseases / metabolism*
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Neuroprotective Agents / metabolism
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Neuroprotective Agents / therapeutic use
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Neurosciences / methods
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Neurosciences / trends*
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Translational Research, Biomedical / methods
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Translational Research, Biomedical / trends*