Abstract
The NADPH oxidase of professional phagocytes has an important role in host defense against certain microbes, including tuberculous mycobacteria. The identification of patients with rare inherited hypomorphic mutations in genes encoding components of this enzyme complex could produce new mechanistic insights.
MeSH terms
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Animals
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Dendritic Cells / immunology
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Humans
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Macrophages / immunology
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Membrane Glycoproteins / immunology
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Models, Biological
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NADPH Oxidase 2
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NADPH Oxidases / immunology
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Phagocytes / classification
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Phagocytes / immunology*
Substances
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Membrane Glycoproteins
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CYBB protein, human
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NADPH Oxidase 2
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NADPH Oxidases