Serum asymmetric dimethylarginine levels in diabetic patients with neuropathy

Diabetes Res Clin Pract. 2011 May;92(2):223-7. doi: 10.1016/j.diabres.2011.01.015. Epub 2011 Feb 12.

Abstract

Objective: The goal of our study was to evaluate the role of asymmetric dimethylarginine (ADMA) in patients with diabetic neuropathy.

Materials and methods: In this study, 58 diabetic patients and 26 healthy volunteers were included. In both groups ADMA measurements were performed together with other biochemical examinations. Nerve conduction studies and Neuropathy Symptom Score (NSS) were administered to the diabetic patients.

Results: ADMA levels were found significantly higher in diabetic patients compared to the control group (p = 0.0001). However, ADMA levels were not statistically significant between diabetic patients with neuropathy and without neuropathy (p = 0.86 and p = 0.47).

Conclusion: These results demonstrate that there is not any significant relationship between ADMA and diabetic neuropathy.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Arginine / analogs & derivatives*
  • Arginine / blood
  • Diabetic Neuropathies / blood
  • Electrophysiology
  • Female
  • Humans
  • Male
  • Middle Aged

Substances

  • N,N-dimethylarginine
  • Arginine