Immunoadsorption (IAS) for systemic lupus erythematosus

Lupus. 2011 Feb;20(2):115-9. doi: 10.1177/0961203310389487.

Abstract

Immunoadsorption (IAS) is used as a rescue therapy in severely ill SLE patients who are refractory to conventional therapies. This extracorporeal method aims at the rapid and extensive removal of pathogenic immunocomplexes (ICs) and (auto-)antibodies (Abs). Although past data have shown short- to mid-term efficacy and biocompatibility of IAS in (renal) SLE, it is still an experimental and rather expensive procedure - and evidence from randomized controlled trials (RCTs) is lacking. Nevertheless, IAS is successfully used in life-threatening situations because of its fast mode of action and its acceptable safety profile.

Publication types

  • Editorial

MeSH terms

  • Antigen-Antibody Complex / immunology
  • Autoantibodies / immunology
  • Humans
  • Immunosorbent Techniques*
  • Lupus Erythematosus, Systemic / immunology*
  • Lupus Erythematosus, Systemic / therapy*
  • Meta-Analysis as Topic
  • Randomized Controlled Trials as Topic
  • Sorption Detoxification / methods*
  • Treatment Outcome

Substances

  • Antigen-Antibody Complex
  • Autoantibodies