Superior mesenteric artery (SMA) syndrome is a rare clinical phenomenon caused by compression of the third portion of the duodenum by the overlying SMA, and can be easily misdiagnosed. We report a case of SMA syndrome treated with laparoscopic duodenojejunostomy omega loop with Braun anastomosis. A 24-year-old women with body mass index of 14.9 presented with a 4-year history of vague abdominal pain mainly at the epigastric region, radiating to the back associated with heartburn, repeated vomiting, and significant loss of weight during the previous 6 months. The case was misdiagnosed as acute pancreatitis. The SMA syndrome was diagnosed using CT-scan and fluoroscopy. Laparoscopic omega loop with Braun anastomosis was preformed. She did well postoperatively, and Gastrografin study showed no leak and a patent anastomosis. She was subsequently discharged on regular diet.