High frequency of PfCRT 76T in two Malian villages and its prevalence in severe relative to non-severe malaria

Acta Trop. 2011 Jul;119(1):11-3. doi: 10.1016/j.actatropica.2011.01.002. Epub 2011 Feb 12.

Abstract

We investigated PfCRT 76T mutation in severe and non-severe malaria in Southern Mali. One hundred and ninety three severe malaria cases were each matched against two non-severe malaria cases. Patients with G6PD deficiency and any known hemoglobin abnormality were excluded. PfCRT 76T was present in 60.8% (n=386) non-severe malaria cases and in 77.2% (n=193) severe malaria cases (p<0.0001). In children 5 years or younger, these proportions were 62.9% (n=294) vs. 73.5% (n=147), respectively (p<0.01). PfCRT 76T was therefore associated with malaria severity in this setting of Mali.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Chloroquine / therapeutic use
  • DNA, Protozoan / analysis
  • DNA, Protozoan / genetics
  • Drug Resistance
  • Female
  • Humans
  • Infant
  • Malaria, Falciparum / drug therapy
  • Malaria, Falciparum / epidemiology*
  • Malaria, Falciparum / parasitology
  • Male
  • Mali / epidemiology
  • Membrane Transport Proteins / genetics*
  • Mutation
  • Plasmodium falciparum / genetics*
  • Plasmodium falciparum / parasitology
  • Prevalence
  • Protozoan Proteins / genetics*
  • Severity of Illness Index

Substances

  • DNA, Protozoan
  • Membrane Transport Proteins
  • PfCRT protein, Plasmodium falciparum
  • Protozoan Proteins
  • Chloroquine