Introduction: Klinefelter syndrome is the commonest chromosomal cause of non-obstructive azoospermia. Despite reports that these men can have children using assisted reproduction techniques, it is not common practice in the Egypt to offer sperm retrieval to these men.
Design: Case report.
Setting: Private IVF center (EIFC-IVF) and a university hospital.
Patient: A 24-year-old woman and a 29-year-old man with non-mosaic Klinefelter syndrome.
Intervention: Testicular sperm extraction followed by intracytoplasmic sperm injection and embryo transfer (TESE-ICSI).
Results: Fifteen immotile sperms were found, five oocytes were injected, and three embryos were transferred. Now the pregnancy is progressing beyond 20 weeks.
Conclusion: Spermatozoa from a patient with non-mosaic Klinefelter syndrome retrieved through TESE can lead to pregnancy.