Ultrasensitivity and positive feedback to promote sharp mitotic entry

Youlian Goulev; Gilles Charvin

doi:10.1016/j.molcel.2011.01.016

Ultrasensitivity and positive feedback to promote sharp mitotic entry

Mol Cell. 2011 Feb 4;41(3):243-4. doi: 10.1016/j.molcel.2011.01.016.

Authors

Youlian Goulev¹, Gilles Charvin

Affiliation

¹ Institut de Biologie Moléculaire et Cellulaire, 1 Rue Laurent Fries, 67400 Illkirch Cedex, France.

PMID: 21292155
DOI: 10.1016/j.molcel.2011.01.016

Abstract

In this issue, Trunnell et al. (2011) show that in mitotic entry the positive feedback that drives the activation of cyclin-dependent kinase (Cdk) involves a very ultrasensitive step of phosphorylation of Cdc25C by Cdk, thus strongly contributing to the switch-like behavior of this essential cell-cycle transition.

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