Oseltamivir-resistant pandemic (H1N1) 2009 virus, Mexico

Emerg Infect Dis. 2011 Feb;17(2):283-6. doi: 10.3201/eid1702.100897.

Abstract

During May 2009-April 2010, we analyzed 692 samples of pandemic (H1N1) 2009 virus from patients in Mexico. We detected the H275Y substitution of the neuraminidase gene in a specimen from an infant with pandemic (H1N1) 2009 who was treated with oseltamivir. This virus was susceptible to zanamivir and resistant to adamantanes and oseltamivir.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adamantane / pharmacology
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • Drug Resistance, Viral* / genetics
  • Female
  • Humans
  • Infant
  • Influenza A Virus, H1N1 Subtype / drug effects*
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza A Virus, H1N1 Subtype / isolation & purification
  • Influenza, Human / drug therapy
  • Influenza, Human / epidemiology*
  • Influenza, Human / prevention & control*
  • Mexico / epidemiology
  • Microbial Sensitivity Tests
  • Neuraminidase / antagonists & inhibitors
  • Neuraminidase / genetics
  • Oseltamivir / administration & dosage
  • Oseltamivir / pharmacology*
  • Oseltamivir / therapeutic use
  • Pandemics*
  • Point Mutation
  • Reverse Transcriptase Polymerase Chain Reaction
  • Zanamivir / pharmacology

Substances

  • Antiviral Agents
  • Oseltamivir
  • Neuraminidase
  • Zanamivir
  • Adamantane