INV(12) (p13q11) and dicentric chromosomes in a secondary leukaemia with basophilia

Haematologica. 1990 Sep-Oct;75(5):473-6.

Abstract

We report on a case of secondary myelodysplasia with basophilia. A karyotype showed 1) the involvement of 12p, which should be related to the basophilia and/or to previous drug exposure, and 2) the unexpected presence of three different dicentric chromosomes.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Basophils / pathology*
  • Blast Crisis / genetics
  • Chromosome Aberrations*
  • Chromosome Inversion
  • Chromosomes, Human, Pair 12 / ultrastructure*
  • Chromosomes, Human, Pair 5 / ultrastructure*
  • Chromosomes, Human, Pair 6 / ultrastructure*
  • Chromosomes, Human, Pair 8 / ultrastructure*
  • Dacarbazine / administration & dosage
  • Dacarbazine / adverse effects
  • Female
  • Humans
  • Leukemia, Myelomonocytic, Chronic / chemically induced
  • Leukemia, Myelomonocytic, Chronic / genetics*
  • Leukemia, Myelomonocytic, Chronic / pathology
  • Melanoma / drug therapy
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects
  • Neoplasms, Multiple Primary*
  • Skin Neoplasms / drug therapy
  • Streptonigrin / administration & dosage
  • Streptonigrin / adverse effects
  • Thiotepa / administration & dosage
  • Thiotepa / adverse effects
  • Vinblastine / administration & dosage
  • Vinblastine / adverse effects

Substances

  • Streptonigrin
  • Vinblastine
  • Dacarbazine
  • Thiotepa
  • Methotrexate