Abstract
We report on a case of secondary myelodysplasia with basophilia. A karyotype showed 1) the involvement of 12p, which should be related to the basophilia and/or to previous drug exposure, and 2) the unexpected presence of three different dicentric chromosomes.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Basophils / pathology*
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Blast Crisis / genetics
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Chromosome Aberrations*
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Chromosome Inversion
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Chromosomes, Human, Pair 12 / ultrastructure*
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Chromosomes, Human, Pair 5 / ultrastructure*
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Chromosomes, Human, Pair 6 / ultrastructure*
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Chromosomes, Human, Pair 8 / ultrastructure*
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Dacarbazine / administration & dosage
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Dacarbazine / adverse effects
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Female
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Humans
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Leukemia, Myelomonocytic, Chronic / chemically induced
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Leukemia, Myelomonocytic, Chronic / genetics*
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Leukemia, Myelomonocytic, Chronic / pathology
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Melanoma / drug therapy
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Methotrexate / administration & dosage
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Methotrexate / adverse effects
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Neoplasms, Multiple Primary*
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Skin Neoplasms / drug therapy
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Streptonigrin / administration & dosage
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Streptonigrin / adverse effects
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Thiotepa / administration & dosage
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Thiotepa / adverse effects
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Vinblastine / administration & dosage
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Vinblastine / adverse effects
Substances
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Streptonigrin
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Vinblastine
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Dacarbazine
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Thiotepa
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Methotrexate