Fis1, Bap31 and the kiss of death between mitochondria and endoplasmic reticulum

EMBO J. 2011 Feb 2;30(3):451-2. doi: 10.1038/emboj.2010.352.

Abstract

A study in this issue of The EMBO Journal sheds light on how mitochondria–ER dynamics, which affect various cell functions, regulate Bax/Bak-driven apoptosis within the complex milieu of the cell. In cell death, these organelles engage in an unanticipated two-way communication, from mitochondria to ER and back again.

Publication types

  • Comment

MeSH terms

  • Apoptosis / physiology*
  • Endoplasmic Reticulum / metabolism
  • Endoplasmic Reticulum / physiology*
  • Membrane Proteins / metabolism*
  • Mitochondria / metabolism
  • Mitochondria / physiology*
  • Mitochondrial Membranes / metabolism*
  • Mitochondrial Proteins / metabolism*
  • Models, Biological
  • Permeability
  • Signal Transduction / physiology*

Substances

  • BCAP31 protein, human
  • FIS1 protein, human
  • Membrane Proteins
  • Mitochondrial Proteins