Abstract
This case-control study evaluated the effect of hysteroscopically identified endometrial polyps on endometrium by means of HOXA10 and HOXA11, known molecular markers of endometrial receptivity. Uteri with endometrial polyps demonstrated a marked decrease in HOXA10 and HOXA11 messenger RNA levels, which may impair implantation. These findings suggest a molecular mechanism to support the clinical findings of diminished pregnancy rates in women with endometrial polyps.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adult
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Case-Control Studies
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Connecticut
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Down-Regulation
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Embryo Implantation* / genetics
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Female
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Fertility* / genetics
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Genetic Markers
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Homeobox A10 Proteins
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Homeodomain Proteins / genetics
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Humans
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Hysteroscopy
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Infertility, Female / etiology*
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Infertility, Female / genetics
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Infertility, Female / physiopathology
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Polyps / complications*
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Polyps / genetics
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Polyps / physiopathology
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Pregnancy
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Pregnancy Rate
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RNA, Messenger / analysis
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Uterine Diseases / complications*
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Uterine Diseases / genetics
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Uterine Diseases / physiopathology
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Uterus / chemistry
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Uterus / physiopathology*
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Young Adult
Substances
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Genetic Markers
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HOXA11 protein, human
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Homeobox A10 Proteins
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Homeodomain Proteins
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RNA, Messenger
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HOXA10 protein, human