Functions of Runx in IgA class switch recombination

Manabu Sugai; Kakeru Watanabe; Yukiko Nambu; Tatsunari Hayashi; Akira Shimizu

doi:10.1002/jcb.22971

Functions of Runx in IgA class switch recombination

J Cell Biochem. 2011 Feb;112(2):409-14. doi: 10.1002/jcb.22971.

Authors

Manabu Sugai¹, Kakeru Watanabe, Yukiko Nambu, Tatsunari Hayashi, Akira Shimizu

Affiliation

¹ Translational Research Center, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan. msugai@virus.kyoto-u.ac.jp

PMID: 21268061
DOI: 10.1002/jcb.22971

Abstract

Runt-related (Runx) transcriptional regulators play essential roles in various cell fate determination processes, and dysfunction of these regulators causes many human diseases. Considerable insight into the functions of Runx proteins was provided mainly by studies of hematopoietic and skeletal disorders. Recently, extensive investigations have revealed new functions of these transcription factors in immune cell differentiation and functioning. In the present review, we discuss the mechanisms of selective IgA production in the intestine and report the involvement of Runx proteins in this process.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Core Binding Factor alpha Subunits / genetics
Core Binding Factor alpha Subunits / metabolism*
Humans
Immunoglobulin A / genetics
Immunoglobulin A / metabolism*
Intestinal Mucosa / metabolism*
Models, Biological

Substances

Core Binding Factor alpha Subunits
Immunoglobulin A