Abstract
A novel series of isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives was synthesized and evaluated in vitro against various human cancer cell lines for antiproliferative activity. These new compounds displayed activity against leukemia and breast cancer cell lines in the 3- to 18-µM concentration range.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Breast Neoplasms / drug therapy
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Female
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Humans
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Inhibitory Concentration 50
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Leukemia / drug therapy
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Models, Molecular
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Molecular Structure
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Quinoxalines / chemical synthesis*
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Quinoxalines / chemistry
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Quinoxalines / pharmacology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Quinoxalines