Abstract
The synthesis and antibacterial activity of several 7 beta-[1-(2-aminothiazol-4-yl)-1-cyclopropanecarboxyamido]cep hem derivatives (1) are described. The structure-activity relationships of 1 are also presented.
MeSH terms
-
Anti-Bacterial Agents / chemistry*
-
Anti-Bacterial Agents / pharmacology
-
Bacteria / drug effects*
-
Cephalosporins / chemistry*
-
Cephalosporins / pharmacology
-
Escherichia coli / drug effects
-
Klebsiella pneumoniae / drug effects
-
Molecular Conformation
-
Proteus vulgaris / drug effects
-
Pseudomonas aeruginosa / drug effects
-
Staphylococcus aureus / drug effects
-
Structure-Activity Relationship
Substances
-
Anti-Bacterial Agents
-
Cephalosporins