Synthesis and antibacterial activity of 7 beta-[1-(2-aminothiazol-4-yl)-1-cyclopropanecarboxyamido]cephem derivatives

J Antibiot (Tokyo). 1990 Oct;43(10):1278-85. doi: 10.7164/antibiotics.43.1278.

Abstract

The synthesis and antibacterial activity of several 7 beta-[1-(2-aminothiazol-4-yl)-1-cyclopropanecarboxyamido]cep hem derivatives (1) are described. The structure-activity relationships of 1 are also presented.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Bacteria / drug effects*
  • Cephalosporins / chemistry*
  • Cephalosporins / pharmacology
  • Escherichia coli / drug effects
  • Klebsiella pneumoniae / drug effects
  • Molecular Conformation
  • Proteus vulgaris / drug effects
  • Pseudomonas aeruginosa / drug effects
  • Staphylococcus aureus / drug effects
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Cephalosporins