Abstract
A direct and facile synthesis of highly functional 5-aza-spiro[2,4]heptanes, a valuable structural motif for drug discovery, is developed via catalytic asymmetric 1,3-dipolar cycloaddition of cyclopropylidene acetate and azomethine ylides for the first time.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aza Compounds / chemistry*
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Azo Compounds / chemistry*
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Catalysis
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Crystallography, X-Ray
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Heptanes / chemical synthesis
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Heptanes / chemistry*
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Molecular Conformation
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Spiro Compounds / chemistry*
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Stereoisomerism
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Thiosemicarbazones / chemistry*
Substances
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Aza Compounds
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Azo Compounds
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Heptanes
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Spiro Compounds
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Thiosemicarbazones
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azomethine