A novel approach to investigate neuronal network activity patterns affected by deep brain stimulation in rats

Julia Klein; Maria L Soto-Montenegro; Javier Pascau; Lydia Günther; Andreas Kupsch; Manuel Desco; Christine Winter

doi:10.1016/j.jpsychires.2010.12.008

A novel approach to investigate neuronal network activity patterns affected by deep brain stimulation in rats

J Psychiatr Res. 2011 Jul;45(7):927-30. doi: 10.1016/j.jpsychires.2010.12.008. Epub 2011 Jan 12.

Authors

Julia Klein¹, Maria L Soto-Montenegro, Javier Pascau, Lydia Günther, Andreas Kupsch, Manuel Desco, Christine Winter

Affiliation

¹ Department of Psychiatry and Psychotherapy, University Medicine Berlin, Charité Campus Mitte, Berlin, Germany.

PMID: 21227451
DOI: 10.1016/j.jpsychires.2010.12.008

Abstract

The establishment of new therapeutic indications for deep brain stimulation (DBS) is ambitiously promoted though the underlying mechanisms remain contested. Here, we report that PET-imaging and subsequent c-Fos-immunostaining in rats constitute a new translational approach to further understand DBS-mechanisms and -effectiveness.

MeSH terms

Animals
Brain / pathology
Brain / physiology*
Deep Brain Stimulation*
Dominance, Cerebral / physiology
Energy Metabolism / physiology
Fluorodeoxyglucose F18
Male
Nerve Net / pathology
Nerve Net / physiology*
Positron-Emission Tomography*
Proto-Oncogene Proteins c-fos / analysis
Rats
Rats, Wistar
Subthalamic Nucleus / pathology
Subthalamic Nucleus / physiology*
Translational Research, Biomedical

Substances

Proto-Oncogene Proteins c-fos
Fluorodeoxyglucose F18